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If you would like to participate online, please contact us at events@ceitec.muni.cz. Online participation is not possible on a one-time basis. It is intended for students whose health and other conditions prevent them from attending on-site during the semester.
We employ a number of advanced biochemical, biophysical, and structural methodologies to understand the intricate role of homologous recombination (HR) in genome stability, disease development, and potential therapeutic applications. Our research focuses on two primarily objectives:
1. Understanding the role and regulation of HR proteins in DNA repair and processing of stalled replication forks: HR plays a dual role in genome maintenance, serving to repair of DNA double-strand breaks. Additionally, HR ensures the protection of arrested replication forks, their reversal, and eventual restart to ensure unhindered replication and sustained genome integrity. The perturbation of recombination mechanisms is intrinsically associated with conditions of human infertility and genetic disorders, including cancer, highlighting the importance of comprehending understanding of this pathway.
2. Development novel potent and selective nucleases inhibitors for therapeutic use: We conduct an in-depth exploration of nucleases, integral components of diverse DNA repair pathways. Deactivation or overexpression of several nucleases poses a threat to genomic stability, contributing to cancer development and providing novel pharmacological targets.
